P53 and glycolysis

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August undefined, 2024

WebFeb 25, 2024 · Regarding the role of p53 on the expression of stress ligands due to metabolic stress, including oxidative stress, is unknown 22, 24. MICA expression in plasma membrane is linked to glycolysis... WebSep 28, 2024 · TP53 is an example of an “undruggable” gene that frequently loses its normal functions and activates a cascade of signaling pathways to promote tumor …

Targeting mutant p53 for cancer therapy: direct and …

WebSep 3, 2008 · Oncogenetic changes involve a nonrandom set of gene deletions, amplifications and mutations, and many oncogenes and tumor suppressor genes cluster along the signaling pathways that regulate c-MYC, HIF-1 and p53. Glycolysis in cancer cells has clinical implications in cancer diagnosis, treatment and interaction with diabetes … WebTP53 or KLF5 inhibition significantly reduced PLA2G16 expression at both mRNA and protein levels. Dual-luciferase and chromatin Immunoprecipitation-quantitative polymerase chain reaction assays showed that KLF5 directly bound to the PLA2G16 promoter and activated its transcription. good names for a ship

JMJD5 inhibits lung cancer progression by regulating glucose

WebNational Center for Biotechnology Information WebFeb 20, 2011 · Through the PPP, p53 suppresses glucose consumption, NADPH production and biosynthesis. The p53 protein binds to glucose-6-phosphate dehydrogenase (G6PD), … WebMar 31, 2024 · The pretreatment of H9c2 with p53 siRNA to knockdown p53 attenuated PHD1 and PHD2 expression, thus significantly enhancing HIF-1α and HIF-2α expression in H9c2 cells under HG conditions. Interestingly, pretreatment with p53 siRNA altered H9c2 cell metabolism by reducing oxygen consumption rate and increasing glycolysis. good names for a shiba inu

Metabolites Free Full-Text Regulation of Metabolic Activity by p53

The potential interplay between G-quadruplex and p53: their roles …

WebDec 9, 2024 · Cancer cells preferentially utilize aerobic glycolysis to provide cancer cells rapid energy production and substrates for biosynthetic pathways (Ward and Thompson, 2012). Cancer cell glycolysis is regulated by activated oncogenes, e.g. Myc (Hsieh et al., 2015), and mutant tumor suppressors, e.g. p53 (Liu et al., 2024). Cancer cell glycolysis is ... Webp53, a well-known tumor suppressor, is deregulated in many cancers. 119 Recently, several studies have revealed that p53 is crucial in cancer glycolysis. The cellular absence of p53 … good names for a sharkWebApr 12, 2024 · However, the role of JMJD5 in p53-mediated metabolic reprogramming remains elusive. Here, we discovered that knockdown of JMJD5 significantly enhances TIGAR expression in p53 wild-type non-small cell lung cancer (NSCLC) cells, which could further suppress glycolysis and promote the pentose phosphate pathway. chesterbrook high school ma

"WebApr 10, 2024 · Evidence that p53 loss and upregulated glycolysis may represent important steps in early tumorigenesis has also been suggested by Kawauchi et al. . They showed that in p53-deficient primary cultured cells, the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was enhanced and this caused an increase in ... " - P53 and glycolysis

P53 and glycolysis

JMJD5 inhibits lung cancer progression by regulating glucose

WebJan 21, 2024 · Wild-type p53 inhibits metabolic shift toward aerobic glycolysis in radioresistant cancer cells. a The p53-null UMSCC1 cells were transduced with wild-type p53 (wt p53) and control vector... WebApr 13, 2024 · The phosphorylated p53 is resistent to degradation by ubiquitination, and p53 promotes transcription of p21 as well, thereby promoting growth arrest and cell senescence (Nacarelli et al. 2024). The p38 MAPK/NF-κB p65 signaling pathway has been reported to induce pro-inflammatory response (Zhao et al. 2014). We found that PEP could active p38 ...

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WebNov 28, 2024 · Recently, mutant p53 proteins have been shown to mediate metabolic changes as a novel GOF to promote tumor development. There is a strong rationale that … WebNational Center for Biotechnology Information

Webp53 abundance and activity in proliferating cells are increased by high rates of glycolysis. To determine how high rates of aerobic glycolysis in cancer cells affect p53, it was … WebMay 5, 2024 · p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators High rates of glycolysis in cancer cells are a well-established characteristic of many human tumors, providing rapidly proliferating cancer cells with metabolites that can be used as precursors for anabolic pathways.

WebOverall, p53 seems to have contradictory roles in glucose metabolism. p53 inhibits glycolysis, which prevents the production of ATP and precursors for biosynthesis, but it also promotes oxidative phosphorylation and the TCA cycle, which produce ATP and precursors for biosynthesis, respectively. WebJul 10, 2024 · Deprivation of serum and glutamine leads to p53 activation respectively through modulation of the PI3K/AKT/MDM2 pathway and the ROS/B55α/EDD pathway. 82, 83 Activated p53 directly induces the...

WebFeb 8, 2024 · p53 inhibits glucose uptake and glycolysis, and promotes a metabolic switch towards the TCA cycle and oxidative phosphorylation, resulting in cuproptosis sensitization. In addition, p53 regulates the biogenesis of iron-sulfur clusters and glutathione, which are two critical components of the cuproptosis pathway, thereby promoting or preventing ...

WebAug 24, 2011 · p53 has been reported to reduce glycolysis and promote mitochondrial respiration in cells. p53 deficiency leads to the Warburg effect in tumors, which is characterized by higher glucose uptake, a higher rate of glycolysis, and higher lactate production in tumor cells than normal cells ( 9, 10 ). good names for a shopWebFeb 8, 2024 · Additionally, p53 regulates the biogenesis of iron-sulfur clusters and the copper chelator glutathione, which are two critical components of the cuproptotic … good names for a shirt businessWebMay 20, 2024 · The influence of p53 on cellular metabolism is complex and involves multiples nodes of regulation (summarised in Figure 1). p53 changes the activity of multiple metabolic pathways, including glycolysis, mitochondrial oxidative phosphorylation and fatty acid synthesis via transcriptional and non-transcriptional regulation. In addition, p53 ... chesterbrook montessori schoolWebNon-canonical functions of p53, such as its roles in glycolysis inhibition, might attenuate or even prevent the Warburg effect. These could contribute to the tumor-suppressive … chesterbrook montessori good names for a skywing wofWebSep 17, 2009 · Several mechanisms have now been described through which p53 can slow glycolysis and therefore counteract the increase in glycolysis that is characteristic of … chesterbrook homes for saleWebJan 26, 2024 · The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor suppressor protein that has multiple aspects of biological function comprising energy metabolism, cell cycle arrest, apoptosis, growth and … good names for a seal