Thbs1 p53

Author: aoej

August undefined, 2024

Web21 Jun 2024 · In addition, the existence of a complex network among p53 family members (p63 and p73) and their interactions with other factors that promote thyroid cancer … Web20 Oct 2011 · We found transcript levels of UCHL1, COL1A2, THBS1 and TNFRSF10D were inversely correlated with promoter methylation. For THBS1 and UCHL1 the effect of this …

Tumor Suppressor p53 Protein Is a New Target for the Metastasis ...

WebThrombospondin 1 antibody (18304-1-AP) Proteintech Featured Product KD/KO Validated Thrombospondin 1 Polyclonal antibody Thrombospondin 1 Polyclonal Antibody for IHC, WB, ELISA Host / Isotype Rabbit / IgG Reactivity human, rat, mouse Applications WB, IHC, IF, ELISA Conjugate Unconjugated Publications 24 Reviews (1) Cat no : 18304-1-AP Synonyms WebOvarian cancer cell lines harboring a TP53 missense mutation bars had lower THBS1 RMA expression compared to cell lines with an intact wild-type (wt) TP53 gene. TP53 missense … intel corporation - display - 30.0.100.9837

THBS1 Protein, Human (HEK 293, His) MedChemExpress

Web8 Oct 2024 · Approach and Results: Using RNA fluorescent in situ hybridization, we identified macrophages being the major source of TSP1 in human and mouse aneurysmal tissues, … Web20 Feb 2024 · Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of … Web04115 p53 signaling pathway 7057 (THBS1) 09144 Cellular community - eukaryotes 04510 Focal adhesion 7057 (THBS1) 09160 Human Diseases 09161 Cancer: overview 05206 … jogo the ants

Thrombospondin 1 antibody (18304-1-AP) Proteintech

Possible mechanisms of TP53 regulation of THBS1

WebThrombospondin 1 (TSP-1), an extracellular matrix protein, is the first identified natural angiogenesis inhibitor. A variety of normal cells, including endothelial cells, fibroblasts, … Web10 Apr 2024 · TGFβ1 stimulation in idiopathic fibrosis significantly increases the activity of SA-β-gal and the levels of senescence-related proteins p21 and p53 in lung fibroblasts. Mannose lectin limits the progression of liver fibrosis by promoting hepatic stellate cellular senescence [ 17 ]. intel corporation - display - 30.0.100.9864Web11 Aug 2014 · To confirm these requirements, we performed complementation studies to determine whether p53 inhibition collaborates with pRB inactivation to repress THBS1 … jogo the amazing spider man

"Webp53 interferes with the DNA binding activity of p53 in vitro and reporter gene transactivation in vivo, and this has a regulatory function. A differential modulation of the p53 target gene … " - Thbs1 p53

Thbs1 p53

Web29 Oct 2013 · THBS1 expression was compared to tumor growth properties. Results: THBS1 gene expression was higher in cells containing a wtTP53 gene or null TP53 mutation (p = …

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Web15 Oct 2015 · The present study marks the first time the effect of S100A4 on mutant p53 levels in gastric cancer MKN1 cells, which harbor mutant p53V143A, and the functional … WebHuman Gene THBS1 (ENST00000260356.6) from GENCODE V43 : Description: Homo sapiens thrombospondin 1 (THBS1), mRNA. (from RefSeq NM_003246) RefSeq Summary …

Web3 Dec 2015 · BRCA1/2 and p53 germline mutation are well known genetic changes that is related to familial AML¡¯s. Because of diverse penetrance potential of germline mutations … WebEntry. hsa04115 Pathway. Name. p53 signaling pathway - Homo sapiens (human) Description. p53 activation is induced by a number of stress signals, including DNA …

Web25 Jun 2024 · TSP1 has several physiological functions in youth, including promoting neural synapse formation, mediating responses to ischemic and genotoxic stress, minimizing hemorrhage, limiting angiogenesis, and supporting wound healing. These acute functions of TSP1 generally require only transient expression of the protein. WebMice lacking Thbs1, the gene that encodes TSP1, have increased vascular density in many tissues ( 24, 25 ), delayed wound healing, altered inflammatory responses, reduced abundance of active transforming growth factor–β (TGF-β) under various challenges, and increased susceptibility to tumor progression due to loss of the normal antiangiogenic …

Web25 May 1999 · Decreased expression of Thrombospondin-1 (THBS1), a P53 and Rb regulated angiogenesis inhibitor, has been observed in some human tumors, including …

Web29 Oct 2013 · The TP53 tumor-suppressor pathway has been implicated in the regulation of THBS1 gene and protein expression ( 1, 9 ). Dameron and colleagues demonstrated that TP53 positively regulated THBS1 promoter sequences and induced endogenous THBS1 gene expression in fibroblasts ( 1 ). jogo the ants para pchttp://cancer-genetics.org/THBS1.htm intel corporation - display - 30.0.100.9955WebLevofloxacin exerts broad-spectrum anticancer activity via regulation of THBS1, LAPTM5, SRD5A3, MFAP5 and P4HA1. ... THBS1 overlapped in 16 of the 22 enriched apoptotic … intel corporation - display - 30.0.101.1371Web29 Oct 2013 · The TP53 tumor-suppressor pathway has been implicated in the regulation of THBS1 gene and protein expression ( 1, 9 ). Dameron and colleagues demonstrated that … intel corporation - display - 30.0.101.1660WebBlockade of THBS1 induction sensitized cells to CB-5083-mediated growth inhibition. Suppression of THBS1 caused an increase of CB-5083-induced sub-G1 population and … jogo the baby in yellowWebActivities and Societies: My PhD dissertation tile is "Characterization of C-Terminal Mutants of the p53 Tumor Suppressor".I used CRISPR/Cas9 technology to mutate the p53 protein … intel corporation - display - 30.0.101.1338Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, collagens t… jogo the ascent